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Ep. 41: “Autoimmunity and Cancer Immunotherapy” Featuring Dr. Vijay Kuchroo

By November 8, 2022February 8th, 2023No Comments

Vijay Kuchroo


Dr. Vijay Kuchroo is the Samuel L. Wasserstrom Professor of Neurology at Harvard Medical School. His major research interests include the role of co-stimulation in autoimmune diseases, as well as cell surface molecules and regulatory factors that regulate the induction of T cell tolerance and dysfunction. He talks about the conditions necessary to differentiate Th17 cells and their role in autoimmunity. He also discusses his group’s discovery of Tim-3, an inhibitor receptor on T cells which is now being exploited for cancer immunotherapy.

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The Immunology Science Round Up

Disrupting Calcium Homeostasis – Researchers showed that inherited variants in ITPR3 alter physiologically relevant Ca2+ signaling responses, driving defects in immune responses.

Light Chain Coherence in Antibodies – Among naturally occurring antibodies that have adapted to particular antigens, those with similar heavy chains usually have similar light chains.

Anti-CTLA-4 Antibodies Reprogram the Tumor Microenvironment – Scientists used single-cell RNA sequencing to dissect the immune response to anti-CTLA-4 blockade.

An Intranasal Booster for Sarbecoviruses – Researchers used a SARS-CoV-2 intranasal spike booster to elicit mucosal immune memory within the respiratory tract.

Image courtesy of Dr. Vijay Kuchroo

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