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Dr. Indira Mysorekar is a Professor of Medicine and Chief of Basic and Translational Research at Baylor College of Medicine. Her lab studies host–microbial interactions in the urinary bladder and the placenta. She discusses the role of the microbiome and the aging immune landscape in recurrent urinary tract infections. She also talks about her research on Zika and SARS-CoV-2 in the placenta.
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The Immunology Science Round Up
Gut Bacteria and Cancer Pathogenesis – Some commensal bacteria promote the development of retrovirus-induced leukemia.
Generating Tolerance to Microbiota – RORγ-expressing cells are responsible for the induction of Tregs in the gut.
Antigen-Presenting Cells Promote Treg Generation – New research reveals parallel pathways for establishing tolerance to self and foreign antigens in the thymus and periphery.
Tissue Destruction in Sjögren’s Syndrome – Sjögren’s syndrome may be caused by self-reactive CD8+ cytotoxic T cells.
CAR T Therapy for Lupus – Anti-CD19 CAR T cell treatment led to remission of systemic lupus erythematosus in a trial of five patients.
Image courtesy of Dr. Indira Mysorekar