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Guest:
Dr. Miriam Merad is Director of the Precision Immunology Institute and a Professor at the Icahn School of Medicine at Mount Sinai. She discusses how myeloid progenitors and macrophages shape the tumor microenvironment, and how dendritic cells support tertiary lymphoid structures and anti-tumor immunity. She also explores the role of chronic inflammation in aging and disease, and shares her perspective on the importance of biomedical research in protecting human health.
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The Immunology Science Round Up
Viral Reactivation in COVID-19 – Chronic viruses frequently reactivate during severe COVID-19, with distinct patterns associated with inflammation, disease severity, recovery, and long COVID.
Safer Antibodies During Pregnancy – Fusing therapeutic antibodies to albumin reduces their transfer across the placenta while preserving prolonged circulation, offering a strategy to limit fetal drug exposure during pregnancy.
Self-Sustaining Regulatory T Cells – Engineering regulatory T cells with a self-sustaining IL-2 signaling system improves their persistence and ability to prevent autoimmune diabetes in mice.
Where Tuberculosis Persists – Mycobacterium tuberculosis persists in lymph nodes by forming infected monocyte-derived niches that evade recognition by Mtb-specific T cells despite activating antimicrobial responses.
Image courtesy of Dr. Miriam Merad.
