Drs. Robert Watson and Kristin Patrick’s labs at Texas A&M University College of Medicine study how the macrophage innate immune response is regulated during bacterial infection. The Watson lab studies the Mycobacterium tuberculosis host-pathogen interface, and is particularly focused how Mtb cytosolic access and mitochondrial homeostasis impact bacterial pathogenesis in macrophages ex vivo and in mouse models of infection. The Patrick lab studies the contributions of RNA binding proteins to macrophage activation and how post-transcriptional regulation of innate immune gene expression (mostly at the level of pre-mRNA splicing) impacts infection outcomes.
Listen to the episode here.