Dr. Scott Canna is an  Associate Professor of Pediatrics (Rheumatology) and Attending Physician, Pediatric Rheumatology and Immune Dysregulation at the Children’s Hospital of Philadelphia. Dr. Canna’s group studies the intersections of hyper- and auto-inflammation. In particular, they study two related disorders, Hemophagocytic Lymphohistiocytosis (HLH) and Macrophage Activation Syndrome, because they typify the concept of hyperinflammation. They combine clinical insights from rheumatology and innate immunity with basic models of overwhelming systemic inflammation to define new disease subtypes and disease activity biomarkers, to flesh out mechanisms of inflammatory disease, and to test promising therapeutic strategies.