Dr. Luke O’Neill is a Professor and Chair of Biochemistry at Trinity College Dublin. His research group is focused on the molecular basis of inflammation, with a particular emphasis on innate immunity and immunometabolism. They and other groups have shown that several metabolites, such as succinate, itaconate, and fumarate, and enzymes, such as PKM2 and GAPDH play specific roles in the immune response in macrophages. They endeavor to provide a better understanding into the metabolic regulation of immune cell function and the innate immune system, with the aim of developing novel therapies to treat inflammatory diseases.

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